bcolz

"bcolz provides columnar, chunked data containers that can be compressed either in-memory and on-disk. Column storage allows for efficiently querying tables, as well as for cheap column addition and removal. It is based on NumPy, and uses it as the standard data container to communicate with bcolz objects, but it also comes with support for import/export facilities to/from HDF5/PyTables tables and pandas dataframes.

bcolz objects are compressed by default not only for reducing memory/disk storage, but also to improve I/O speed. The compression process is carried out internally by Blosc, a high-performance, multithreaded meta-compressor that is optimized for binary data (although it works with text data just fine too).

bcolz can also use numexpr internally (it does that by default if it detects numexpr installed) or dask so as to accelerate many vector and query operations (although it can use pure NumPy for doing so too). numexpr/dask can optimize the memory usage and use multithreading for doing the computations, so it is blazing fast. This, in combination with carray/ctable disk-based, compressed containers, can be used for performing out-of-core computations efficiently, but most importantly transparently."

https://github.com/Blosc/bcolz